7 Questions About Biologics People With Spinal Inflammation Should Ask Their Doctors

Learning about your treatment options is one major aspect of managing a chronic condition that causes spinal inflammation, such as ankylosing spondylitis. It can also be really frustrating since you may need to try several treatments before finding something that helps relieve your symptoms.

You might be interested in taking biologics, a type of medication that targets your body’s immune system to lower inflammation. Generally, doctors recommend biologics for ankylosing spondylitis when you’ve already tried nonsteroidal anti-inflammatory (NSAID) drugs and your symptoms haven’t improved, according to Dona Poulose, M.D.,1 assistant professor of allergy, immunology, and rheumatology at the Baylor College of Medicine.

There are numerous types of biologics, and the right medication for you depends on several factors—including what exactly is causing your spinal inflammation. If you are interested in taking biologics, it’s important to understand what your treatment plan may involve, and how it can help you manage your symptoms. Here are some questions about biologics that you might find helpful to ask at your doctor appointment.

1. Which biologic would you recommend for me and why?

After determining that you’re a candidate for biologics, your doctor may suggest a few for you based on several factors, according to ​​Orrin Troum, M.D.,2 rheumatologist at Providence Saint John’s Health Center in Santa Monica. For many people, insurance coverage is a big determinant. “I may like someone to use a particular medication because others have had good experiences with it, but if their insurance coverage is going to make it difficult, we’ll try something else,” Dr. Troum tells SELF. (If you don’t have health insurance or if your insurance doesn’t cover biologics, then you can contact the drug manufacturer to ask about patient assistance programs, which can help cover some of the medication cost.)

Your doctor will also factor in whether you have any comorbidities or allergies when selecting your biologic, Dr. Poulose says. (Some medications may work better or be safer in people with certain other health conditions.3)

2. What are the side effects of taking this biologic?

You want to have a clear understanding of the possible risks that come with taking medications, so it’s worth asking about side effects if your doctor doesn’t bring them up.

Biologics are administered either through an intravenous infusion or injected under the skin, so you may experience pain and swelling around the injection site, according to the Johns Hopkins Arthritis Center.4Reactions around the biologic injection site are the most common side effect; however, you may also develop infections more easily when using these medications.

There’s no way of knowing how you might react to a medication. But if you’re worried about side effects, you can ask your doctor questions that can give you some perspective such as:

  • How can side effects affect my daily life?
  • What can we do if my side effects are worrisome?
  • What are the most common side effects you see in other patients?

3. Will I need any additional treatments?

You might assume that taking a biologic is the only treatment that you’ll need, but that’s not always the case. For example, some people with ankylosing spondylitis may find that physical therapy can be a really helpful addition to their medication, according to Dr. Poulose. “Physical therapy is vital to preserve mobility and help prevent stiffness,” Dr. Poulose tells SELF. In physical therapy, you might walk, stretch, and even try new sleep positions that help preserve your posture. Depending on your particular condition and symptoms, your doctor may also prescribe additional pain medications such as corticosteroid injections, Dr. Troum says.

4. What kind of progress can I expect?

This is hard to predict, but it’s still a good question to ask. “Not every patient responds the same to every medication,” Dr. Poulose says.

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