Cardinals Vs 49ers Week 5 NFL Betting Odds & Trends | 10/10/2021

The Arizona Cardinals (4-0) will look to keep their four-game winning streak intact when they face the San Francisco 49ers (2-2) in Week 5. The Cardinals (-5) play host to the 49ers (+190 on the moneyline to win) on October 10, 2021 at 4:25 PM ET on FOX. A point total of 48 points has been set for the game.

In this article you’ll discover everything you need to know to place a bet on the game, including injury updates, key metrics, and weather conditions, as well as up-to-date odds.

The betting insights in this article reflect betting data from DraftKings as of October 9, 2021, 8:18 PM ET. See the table below for current betting odds and CLICK HERE to bet at DraftKings Sportsbook.

Cardinals Vs. 49ers Betting Odds

Cardinals Vs. 49ers Player Props

Cardinals Vs. 49ers Betting Angles

This feed is updated automatically when something happens.

Cardinals Vs. 49ers Weather

The weather report for Glendale on Sunday is dry (clear sky) and relatively calm (3 mph winds), with a high temperature of 82 degrees Fahrenheit (as of 8:18 PM on October 9). But this game could be played inside because State Farm Stadium has a retractable roof.

Cardinals Vs. 49ers Injury Report

Arizona Injuries

Player Pos. Injury Status
Kelvin Beachum OT Ribs Questionable
Jack Crawford DE Undisclosed Out
Jordan Phillips DE Undisclosed Questionable
Justin Murray OT Back Out
Charles Washington FS Hamstring Out
Joshua Miles OT Ankle Out
Eno Benjamin RB Hamstring Questionable
Antonio Hamilton CB Ankle Questionable
Chase Edmonds RB Shoulder Questionable
Byron Murphy Jr. CB Ribs Out
Maxx Williams TE Shoulder Questionable
Darrell Daniels TE Covid-19 Out
Marco Wilson CB Ribs Questionable

San Francisco Injuries

Player Pos. Injury Status
George Kittle TE Calf Out
Samson Ebukam OLB Hamstring Questionable
Javon Kinlaw DT Knee Questionable
Robbie Gould K Groin Out
Josh Norman CB Chest Probable
Jimmy Garoppolo QB Calf Out
K’Waun Williams CB Calf Out
Jason Verrett CB Torn Acl Out
Raheem Mostert RB Knee Out
Jordan Willis DE Suspension Out
Tarvarius Moore FS Achilles Out
Davontae Harris CB Undisclosed Questionable
Jeff Wilson Jr. RB Knee Out
Kevin Givens DT Ankle Out
Dre Greenlaw OLB Groin Out
Jalen Hurd WR Knee Out
Justin Skule OT Acl Out
JaMycal Hasty RB Ankle Out
Elijah Mitchell RB Shoulder Probable

Cardinals Offense Vs. 49ers Defense

Cardinals Offense Stats (Rank) 49ers Defense
35.0 (1) Points/Gm 25.5 (22)
0.53 (2) Points/Play 0.40 (21)
440.5 (1) Yards/Gm 336.3 (10)
318.3 (3) Pass Yards/Gm 234.5 (10)
136.5 (6) Rush Yards/Gm 118.0 (17)
6.6 (3) Yards/Play 5.3 (10)
9.5 (1) Yards/Pass 6.8 (10)
4.4 (10) Yards/Rush 4.5 (20)
43.2% (9) 3rd Down % 33.3% (9)
72.2% (8) Red Zone % 78.6% (26)
4 (9) Turnovers 1 (31)
8 (12) Sacks 9 (13)

49ers Offense Vs. Cardinals Defense

49ers Offense Stats (Rank) Cardinals Defense
26.8 (7) Points/Gm 21.3 (9)
0.41 (10) Points/Play 0.33 (9)
375.8 (16) Yards/Gm 357.3 (15)
271.8 (12) Pass Yards/Gm 240.3 (11)
114.5 (12) Rush Yards/Gm 135.8 (26)
5.8 (13) Yards/Play 5.6 (15)
7.9 (13) Yards/Pass 6.7 (8)
3.9 (20) Yards/Rush 5.4 (31)
37.5% (21) 3rd Down % 32.6% (6)
100.0% (1) Red Zone % 61.5% (16)
6 (25) Turnovers 9 (3)
7 (6) Sacks 9 (13)

When The Cardinals Have The Ball

  • The Cardinals offense is ninth-ranked in the league in terms of turnovers allowed (4), and are facing the 31st-ranked team in turnovers forced, the 49ers (1).
  • Arizona’s top-ranked scoring offense averages 35.0 points per game. San Francisco has the 22nd-ranked scoring defense (25.5 ppg).
  • The Cardinals’ offense averages 0.53 points per play (second in the NFL) compared to the 0.40 per play the 49ers’ defense gives up (21st in the league).
  • San Francisco allows a score on 78.6% of its opponents’ red-zone appearances (26th in the league), while Arizona’s offensive red-zone percentage is 72.2% (eighth).

When The 49ers Have The Ball

  • The 49ers rank 25th in the league, committing six turnovers this season, while the Cardinals are third with nine turnovers forced.
  • Arizona allows a score on 61.5% of its opponents’ red-zone appearances (16th in the league), while San Francisco’s offensive red-zone percentage is 100.0% (first).
  • The 49ers have a 37.5% third-down conversion rate, 21st in the NFL. The Cardinals allow third-down conversions on 32.6% of their opponents’ attempts (sixth).
  • San Francisco’s rushing game ranks 12th in the NFL (114.5 yards per game). Arizona gives up 135.8 rushing yards per game (26th).

Cardinals Betting Trends And Insights

  • Arizona has covered three times in four games with a spread this season.
  • The Cardinals have covered the spread when playing as at least 5-point favorites in their only opportunity this season.
  • Arizona’s games have gone over the point total twice this season.
  • Arizona’s four games this season have all gone over this contest’s total of 48 points.
  • The Cardinals have been listed as the moneyline favorite just two other times so far this season, and they won both of the games.

49ers Betting Trends And Insights

  • San Francisco has won one game against the spread this season.
  • So far this season, two of San Francisco’s games have gone over the point total.
  • San Francisco has played three games this season that ended with a combined score higher than 48 points.
  • This is the first time the 49ers will play as underdogs this season.

Cardinals Players To Watch

  • Kyler Murray has thrown for 1,273 yards while connecting on 76.1% of his passes (102-for-134), with nine touchdowns and four interceptions (318.3 yards per game). He’s also carried the ball 23 times for 109 yards and three touchdowns.
  • Chase Edmonds has run for a team-high 255 yards (63.8 per game) and zero touchdowns. He also has 140 receiving yards on 20 catches .
  • So far this year James Conner has run for 172 yards (43.0 per game), with four touchdowns.
  • A.J. Green has 15 catches (24 targets) and paces his team with 248 receiving yards (62.0 ypg) and two touchdowns.
  • Christian Kirk has 16 catches for 244 yards (61.0 per game) and two touchdowns.
  • DeAndre Hopkins is averaging 56.3 yards per game, with 17 catches for 225 yards and three touchdowns.
  • Chandler Jones has 5.0 sacks to lead the team, and has also collected 5.0 TFL and nine tackles.
  • This season Budda Baker has totaled 30 tackles and 2.0 TFL, leading his team in tackles.
  • Byron Murphy has intercepted three passes to lead the team while adding 14 tackles and six passes defended.

49ers Players To Watch

  • Jimmy Garoppolo has passed for 925 yards (78-of-118), with five touchdowns and two interceptions (231.3 yards per game).
  • Elijah Mitchell has churned out a team-best 146 rushing yards (36.5 per game) and one touchdown.
  • So far this season Trey Sermon has run for 128 yards on 30 carries (32.0 yards per game), with one touchdown.
  • Deebo Samuel has 28 catches (43 targets) and paces his team with 490 receiving yards (122.5 per game) while scoring three touchdowns.
  • George Kittle has contributed with 19 receptions (on 28 targets) for 227 yards.
  • Kyle Juszczyk has caught 11 passes on 12 targets for 100 yards and one touchdown.
  • Nick Bosa has registered a team-leading 4.0 sacks, while adding 6.0 TFL and 14 tackles.
  • Fred Warner has collected 36 tackles and 2.0 TFL, and he’s tops on his team in tackles.
  • This season Javon Kinlaw leads the team with zero interceptions and has added eight tackles.

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